Metabolic Regulation of Pluripotent Stem Cell Expansion, Differentiation, and Reprogramming
نویسندگان
چکیده
from OXPHOS to glycolysis [6]. The pluripotent marker OCT4 affects several target genes (e.g. ATP5D) associated with energy metabolism which are in favor of glycolysis [1]. Various new hPSC culture systems have been developed in recent years, including defined serum-free media (e.g., mTESR, StemPro, and E8) and synthetic substrates (e.g., synthemax) [7,8]. How the subtle differences in these culture conditions affect energy balance and the differentiation efficiency of hPSCs needs to be explored.
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